和铂医药(02142.HK)与艾伯维就新冠抗体启动临床试验,强大创新能力获国际验证
格隆汇12月15日丨和铂医药(02142.HK)今日宣布由其与乌得勒支大学共同授权艾伯维的针对COVID-19和相关冠状病毒预防和治疗的全人源中和抗体ABBV- 47D11,已开展一期临床试验。艾伯维将先行在美国开展该临床研究项目,并扩展至欧洲地区。和铂医药的H2L2全人源转基因小鼠平台能够快速发现和开发有效候选药物,其中ABBV-47D11成为此次理想的候选药物。该抗体靶向SARS-CoV-2的保守区域,迄今为止通过合作的临床前研究表明,针对该靶点的抗体对当下的疫情具有良好的治疗潜力,包括一系列潜在逃逸突变。在临床前研究中,该抗体表现出阻断SARS-CoV-2以及SARS-CoV-1感染的潜力。根据授权协议,艾伯维将为该抗体的权益向和铂医药及乌得勒支大学支付一次性权益转让费与特许开发、监管和销售的阶段性费用,以及商业销售净额的分级使用费。和铂医药通过其享有全球专利的抗体发现平台开展包括该项目在内的诸多对外授权共同发现/开发项目,该项目的顺利进展体现了和铂医药强大的创新研发能力以及国际领先的行业伙伴对和铂医药抗体发现平台的高度认可。
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